PD 123319

Research use only, not for human use.

A potent, selective, non-peptide AT2 receptor with IC50 of 34 nM.

A potent, selective, non-peptide AT2 receptor with IC50 of 34 nM.Heart Failure Discontinued.

PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues.?125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on?125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM).?

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PD123319 | PD-123319 | (S)-(+)-PD 123319

GPCR/G Protein

Angiotensin Receptor

AT2receptor

Cardiovascular Disease

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130663-39-7

508.6108

C31H32N4O3

>98% (HPLC)

10 mM in DMSO

CC1=C(C=CC(=C1)CN2C=NC3=C2C[C@H](N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C

1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-

(-20℃)

With Ice Pack

≥ 2 years