Escitalopram

Research use only, not for human use.

Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.

Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.

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Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats.Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively . Animal Model:Male Sprague-Dawley ratsDosage:10 mg/kg Administration:I.p.; daily for 28 days Result:Could selectively decrease phosphorylated tau accumulation in the hippocampus of stressed rats and could distinctly alleviate the hyperactivity of the HPA axis in both depressive and resistant rats.Animal Model:APP-PS1 hemizygous female mice (4 months of age)Dosage:2.5-5 mg/kg Administration:Daily; drinking water for a total of 4 months Result:At both doses significantly reduced plaque burden within the brains of these mice compared to littermate controls that drank only water. Hippocampal plaque load was significantly reduced by 28.7% and 34.4 % for ESC 2.5 mg/day and 5 mg/day, respectively.

(S)-Citalopram

Endocrinology/Hormones

5-HT Receptor

Sert (Sodium-dependent)| mAChR| α-adrenergic receptor| DA transporter| H1 receptor| Noradrenaline transporter (Sodium-dependent)

Neurological Disease

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128196-01-0

414.43

C20H21FN2O·C2H2O4

>98% (HPLC)

DMSO: ≥15 mg/mL

N#CC1=CC2=C([C@@](C3=CC=C(F)C=C3)(CCCN(C)C)OC2)C=C1

(S)-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

(-20℃)

With Ice Pack

≥ 2 years