Paromomycin Sulfate

Research use only, not for human use.

Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.

Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.(In Vitro):Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells.(In Vivo):Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum and only 10% of focal inflammation at 200 mg/kg.

Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells.

Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum and only 10% of focal inflammation at 200 mg/kg. Animal Model:Male Swiss albino miceDosage:50 mg/kg-200 mg/kg Administration:Oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infectionResult:Was against cryptosporidiosis in vivo.

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GPCR/G Protein

Antibacterial

16S rRNA

Infection

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1263-89-4

713.71

C23H47N5O18S

>98% (HPLC)

Water: 100 mg/mL (140.11 mM)

C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

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(-20℃)

With Ice Pack

≥ 2 years