NIBR-3049( TCS-21311 )

Catalog No. M11072 CAS No. 1260181-14-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NIBR-3049
Note

Research use only, not for human use.
Brief Description

NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM.
Description

NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively.
In Vitro

TCS 21311 (NIBR3049) exhibits IC50 values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively?in a enzymatic Jak assay.TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC50=689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity.
In Vivo

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Synonyms

TCS-21311
Pathway

Angiogenesis
Target

JAK
Recptor

JAK
Research Area

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Indication

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CAS Number

1260181-14-3
Formula Weight

526.51
Molecular Formula

C27H25F3N4O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (189.93 mM)
SMILES

O=C(C(C1=CC(N2CCN(C(C(C)(O)C)=O)CC2)=CC=C1C(F)(F)F)=C3C4=CNC5=C4C=CC=C5)NC3=O
Chemical Name

3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

1. Thoma G, et al. J Med Chem. 2011 Jan 13;54(1):284-8.

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