Cart
sales@molnova.com
CEP-33779
CAS No. 1257704-57-6
CEP-33779( CEP33779 | CEP-33779 | CEP 33779. )
Catalog No. M11060 CAS No. 1257704-57-6
CEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
|
| 2MG | 51 | In Stock |
|
| 5MG | 85 | In Stock |
|
| 10MG | 140 | In Stock |
|
| 25MG | 244 | In Stock |
|
| 50MG | 368 | In Stock |
|
| 100MG | 548 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1190 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCEP-33779
-
NoteResearch use only, not for human use.
-
Brief DescriptionCEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.
-
DescriptionCEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.
-
In Vitro——
-
In Vivo——
-
SynonymsCEP33779 | CEP-33779 | CEP 33779.
-
PathwayAngiogenesis
-
TargetJAK
-
RecptorJAK2,JAK3
-
Research AreaInflammation/Immunology
-
Indication——
Chemical Information
-
CAS Number1257704-57-6
-
Formula Weight462.57
-
Molecular FormulaC24H26N6O2S
-
Purity>98% (HPLC)
-
SolubilityDMSO:93 mg/mL (201.05 mM); Ethanol:<1 mg/mL (<1 mM); Water：<1 mg/mL (<1 mM)
-
SMILESO=S(C1=CC=C(C2=CC=CN3C2=NC(NC4=CC=CC(N5CCN(C)CC5)=C4)=N3)C=C1)(C)=O
-
Chemical NameN-(3-(4-methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Dugan BJ, et al. A selective, orally bioavailable 1,2,4-triazolo1,5-apyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779. J Med Chem. 2012 Jun 14;55(11):5243-54.
2. Seavey MM, et al. Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer. Mol Cancer Ther. 2012 Apr;11(4):984-93.
molnova catalog
related products
-
Atiprimod
Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.
-
AZD 4205
AZD 4205 (AZD4205) is a potent, selective JAK1 inhibitor IC50 of 73 nM and Ki of 2.8 nM, shows high selectivity against JAK2 and JAK3 with IC50 of 13,233 nM and >30,000 nM respectively.
-
Povorcitinib phospha...
Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.
