JTE-952( JTE952 | JTE 952 )

Catalog No. M11037 CAS No. 1255303-54-8

COA

Datasheet

HNMR

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Product Name

JTE-952
Note

Research use only, not for human use.
Brief Description

JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM.
Description

JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM, shows cellular activity in BMMCs IL-6 secretion assays with IC50 of 20 nM; JTE-952 is also effective against a mouse collagen-induced model of arthritis (mouse CIA-model).
In Vitro

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In Vivo

JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model). Animal Model:Mouse model of collagen-induced arthritis (CIA model).Dosage:3 mg/kg.Administration:Oral once-daily.Result:Reduced the overall progression of the clinical score, including inflammation and bone erosion.
Synonyms

JTE952 | JTE 952
Pathway

Tyrosine Kinase
Target

CSF1R
Recptor

CSF1R
Research Area

——
Indication

——

CAS Number

1255303-54-8
Formula Weight

518.61
Molecular Formula

C30H34N2O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (192.83 mM)
SMILES

O=C(N1CC(C2=CC=C(OCC3=CC=C(C4CC4)C=C3)C(OC)=C2)C1)C5=NC=CC(COC[C@@H](O)CO)=C5
Chemical Name

(S)-(3-(4-((4-cyclopropylbenzyl)oxy)-3-methoxyphenyl)azetidin-1-yl)(4-((2,3-dihydroxypropoxy)methyl)pyridin-2-yl)methanone

1. Ikegashira K, et al. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877.

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