AZD-1979( AZD1979 | AZD 1979 )

Catalog No. M11025 CAS No. 1254035-84-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AZD-1979
Note

Research use only, not for human use.
Brief Description

A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM.
Description

A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM; shows no apparent affinity for MCHR2 (Ki>40 uM); dose-dependently reduces body weight in DIO mice leading to improved homeostasis model assessment-index of insulin sensitivity.Obesity Phase 1 Clinical.
In Vitro

——
In Vivo

In DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake, but an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs.
Synonyms

AZD1979 | AZD 1979
Pathway

GPCR/G Protein
Target

MCHR
Recptor

MCHR
Research Area

Metabolic Disease
Indication

Obesity

CAS Number

1254035-84-1
Formula Weight

462.506
Molecular Formula

C25H26N4O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 33.33 mg/mL (72.06 mM)
SMILES

O=C(N1CC(OC2=CC=C(CN(C3)CC43COC4)C=C2)C1)C5=NN=C(C6=CC=C(OC)C=C6)O5
Chemical Name

(3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

1. Johansson A, et al. J Med Chem. 2016 Mar 24;59(6):2497-511. 2. Ploj K, et al. Br J Pharmacol. 2016 Sep;173(18):2739-51.

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