P-50429( P50429 | P 50429 )

Catalog No. M11001 CAS No. 1247825-37-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

P-50429
Note

Research use only, not for human use.
Brief Description

P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.
Description

P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs; exhibits 20-fold more potent inhibition of USP7 compared with P22077 (IC50 0.42 versus 8.0 uM); destabilizes HDM2, increases p53 and the downstream target p21, inhibits the proliferation of HCT-116 cells.
In Vitro

USP7/USP47 inhibitor (compound 14) is a selective inhibitor of USP7/USP47 with EC50s of 0.42 μM and 1 μM, respectively. USP7/USP47 inhibitor does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC50 > 31.6 μM). USP7/USP47 inhibitor inhibits the growth of HCT-116 cells with an EC50 of 7.6 μM.
In Vivo

——
Synonyms

P50429 | P 50429
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

USP7|USP47
Research Area

Cancer
Indication

——

CAS Number

1247825-37-1
Formula Weight

484.3992
Molecular Formula

C18H11Cl2N3O3S3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 44 mg/mL
SMILES

O/C(C1=CC(C#N)=C(SC2=C(Cl)C=NC=C2Cl)S1)=N\C3=CC=C(S(=O)(C)=O)C=C3
Chemical Name

2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-

1. Weinstock J, et al. ACS Med Chem Lett. 2012 Sep 11;3(10):789-92. 2. Pozhidaeva A, et al. Cell Chem Biol. 2017 Oct 4. pii: S2451-9456(17)30330-6.

Calculator

molnova catalog