Neladenoson dalanate hydrochloride( BAY 10-67197 )

Catalog No. M10960 CAS No. 1239235-25-6

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Product Name

Neladenoson dalanate hydrochloride
Note

Research use only, not for human use.
Brief Description

Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure.
Description

Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure.Heart Failure Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

BAY 10-67197
Pathway

Apoptosis
Target

Adenosine Receptor
Recptor

Adenosine Receptor
Research Area

——
Indication

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CAS Number

1239235-25-6
Formula Weight

752.73
Molecular Formula

C35H35Cl2N7O4S2
Purity

>98% (HPLC)
Solubility

——
SMILES

C[C@@H](C(OCCOC1=CC=C(C2=C(C#N)C(SCC3=CSC(C4=CC=C(Cl)C=C4)=N3)=NC(N5CCCC5)=C2C#N)C=C1)=O)NC([C@H](C)N)=O.[H]Cl
Chemical Name

2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol- 4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin- 4-yl]phenoxy}ethyl L-alanyl-L-alaninate hydrochloride

1. Meibom D, et al. ChemMedChem. 2017 May 22;12(10):728-737. 2. Voors AA, et al. J Clin Pharmacol. 2017 Apr;57(4):440-451.

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