NC-001( NC 001 | NC001 | az-NC-001 )

Catalog No. M10954 CAS No. 1237540-68-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NC-001
Note

Research use only, not for human use.
Brief Description

NC-001 (NC 001, NC001, az-NC-001) is a potent, specific, cell-permeable inhibitor of immunoproteasome caspase-like sites (β1i and β1).
Description

NC-001 (NC 001, NC001, az-NC-001) is a potent, specific, cell-permeable inhibitor of immunoproteasome caspase-like sites (β1i and β1), does not correlate with inhibition of chymotrypsin-like sites.
In Vitro

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In Vivo

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Synonyms

NC 001 | NC001 | az-NC-001
Pathway

Proteasome/Ubiquitin
Target

Proteasome
Recptor

Proteasome
Research Area

——
Indication

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CAS Number

1237540-68-9
Formula Weight

535.646
Molecular Formula

C25H41N7O6
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

(S)-1-((2-azidoacetyl)-L-alanyl)-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxohexan-2-yl)pyrrolidine-2-carboxamide

1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89. 2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.

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