Cart
sales@molnova.com
Epetraborole hydrochloride
CAS No. 1234563-16-6
Epetraborole hydrochloride( GSK2251052 hydrochloride | AN3365 )
Catalog No. M10938 CAS No. 1234563-16-6
Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 162 | In Stock |
|
| 5MG | 161 | In Stock |
|
| 10MG | 258 | In Stock |
|
| 25MG | 464 | In Stock |
|
| 50MG | 681 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameEpetraborole hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionEpetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS).
-
DescriptionEpetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates; MIC90s against 302 Bacteroides fragilis and Bacteroides thetaiotaomicron strains are 4 and 8 μg/ml, respectively; a single amino acid polymorphism (P329) within the editing domain of LeuRS reduces susceptibility to GSK2251052.Bacterial Infection Phase 2 Discontinued
-
In VitroEpetraborole (0-32 μg/mL) shows anti-bacterial activity against key gram-negative aerobic and anaerobic pathogens and gram-positive anaerobes. Cell Viability Assay Cell Line:Anaerobes isolates Concentration:0-32 μg/mL Incubation Time:Result:Showed MIC50/MIC90 for all anaerobes isolates tested of 2 and 4 μg/mL, respectively.
-
In Vivo——
-
SynonymsGSK2251052 hydrochloride | AN3365
-
PathwayGPCR/G Protein
-
TargetAntibacterial
-
RecptorbacterialleucyltRNAsynthetase
-
Research AreaInfection
-
IndicationBacterial Infection
Chemical Information
-
CAS Number1234563-16-6
-
Formula Weight273.521
-
Molecular FormulaC11H17BClNO4
-
Purity>98% (HPLC)
-
SolubilityH2O: ≥ 28 mg/mL
-
SMILESB1(C2=C(C=CC=C2OCCCO)C(O1)CN)O.Cl
-
Chemical Name1-Propanol, 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-, hydrochloride (1:1)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Goldstein EJ, et al. Antimicrob Agents Chemother. 2013 May;57(5):2401-4.
2. Tenero D, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3334-9.
3. O'Dwyer K, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.
4. Gupta A, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3219-21.
molnova catalog
related products
-
Pachybasin
Pachybasin is an anthraquinone fungal metabolite. Pachybasin shows antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively.
-
Omadacycline
Omadacycline a new tetracycline antibiotic can inhibit the 30s subunit of bacterial ribosome.
-
DIMBOA
DIMBOA, an antibiotic, is a benzoxazinoid, part of the chemical defense system of graminaceous plants such as maize, wheat, and rye.
