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Epetraborole hydrochloride
CAS No. 1234563-16-6
Epetraborole hydrochloride( GSK2251052 hydrochloride | AN3365 )
Catalog No. M10938 CAS No. 1234563-16-6
Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 162 | In Stock |
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| 5MG | 161 | In Stock |
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| 10MG | 258 | In Stock |
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| 25MG | 464 | In Stock |
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| 50MG | 681 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEpetraborole hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionEpetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS).
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DescriptionEpetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates; MIC90s against 302 Bacteroides fragilis and Bacteroides thetaiotaomicron strains are 4 and 8 μg/ml, respectively; a single amino acid polymorphism (P329) within the editing domain of LeuRS reduces susceptibility to GSK2251052.Bacterial Infection Phase 2 Discontinued
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In VitroEpetraborole (0-32 μg/mL) shows anti-bacterial activity against key gram-negative aerobic and anaerobic pathogens and gram-positive anaerobes. Cell Viability Assay Cell Line:Anaerobes isolates Concentration:0-32 μg/mL Incubation Time:Result:Showed MIC50/MIC90 for all anaerobes isolates tested of 2 and 4 μg/mL, respectively.
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In Vivo——
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SynonymsGSK2251052 hydrochloride | AN3365
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorbacterialleucyltRNAsynthetase
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Research AreaInfection
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IndicationBacterial Infection
Chemical Information
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CAS Number1234563-16-6
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Formula Weight273.521
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Molecular FormulaC11H17BClNO4
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 28 mg/mL
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SMILESB1(C2=C(C=CC=C2OCCCO)C(O1)CN)O.Cl
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Chemical Name1-Propanol, 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Goldstein EJ, et al. Antimicrob Agents Chemother. 2013 May;57(5):2401-4.
2. Tenero D, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3334-9.
3. O'Dwyer K, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.
4. Gupta A, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3219-21.
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