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RV1088
CAS No. 1229606-73-8
RV1088( RV-1088 | RV 1088 )
Catalog No. M10903 CAS No. 1229606-73-8
RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameRV1088
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NoteResearch use only, not for human use.
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Brief DescriptionRV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually.
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DescriptionRV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM; also reduces IL-6 production effectively with IC50 of 1.66 nM, RV1088 is significantly more effective at inhibiting IL-6 and IL-8 production by monocytes and RA synovial fibroblasts compared with Humira; TNF-α, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50s.
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In Vitro——
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In Vivo——
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SynonymsRV-1088 | RV 1088
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38 MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number1229606-73-8
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Formula Weight578.673
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Molecular FormulaC33H34N6O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxyacetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. To WS, et al. Br J Pharmacol. 2015 Aug;172(15):3805-16.
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