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XE 991 dihydrochloride

CAS No. 122955-13-9

XE 991 dihydrochloride( XE-991 | XE991 )

Catalog No. M10900 CAS No. 122955-13-9

A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 93 In Stock
5MG 92 In Stock
10MG 147 In Stock
25MG 281 In Stock
50MG 423 In Stock
100MG 635 In Stock
200MG 883 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    XE 991 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.
  • Description
    A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively; displays 14-fold less potency for KCNQ1+minK current with Kd of 11 uM, enhances hippocampal ACh release from rat brain slices (EC50=490 nM) and is a cognitive enhancer in vivo.Alzheimer Disease Discontinued.
  • In Vitro
    XE991 dihydrochloride possesses an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action.
  • In Vivo
    ——
  • Synonyms
    XE-991 | XE991
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    122955-13-9
  • Formula Weight
    449.37
  • Molecular Formula
    C26H20N2O.2HCl
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 11.11 mg/mL (24.72 mM)
  • SMILES
    O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15
  • Chemical Name
    10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30. 2. Wang HS, et al. Mol Pharmacol. 2000 Jun;57(6):1218-23. 3. MacVinish LJ, et al. Mol Pharmacol. 2001 Oct;60(4):753-60. 4. Yeung SY, et al. Br J Pharmacol. 2005 Oct;146(4):585-95.
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