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XE 991 dihydrochloride
CAS No. 122955-13-9
XE 991 dihydrochloride( XE-991 | XE991 )
Catalog No. M10900 CAS No. 122955-13-9
A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 281 | In Stock |
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| 50MG | 423 | In Stock |
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| 100MG | 635 | In Stock |
|
| 200MG | 883 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameXE 991 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.
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DescriptionA potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively; displays 14-fold less potency for KCNQ1+minK current with Kd of 11 uM, enhances hippocampal ACh release from rat brain slices (EC50=490 nM) and is a cognitive enhancer in vivo.Alzheimer Disease Discontinued.
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In VitroXE991 dihydrochloride possesses an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action.
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In Vivo——
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SynonymsXE-991 | XE991
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number122955-13-9
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Formula Weight449.37
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Molecular FormulaC26H20N2O.2HCl
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 11.11 mg/mL (24.72 mM)
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SMILESO=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15
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Chemical Name10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
2. Wang HS, et al. Mol Pharmacol. 2000 Jun;57(6):1218-23.
3. MacVinish LJ, et al. Mol Pharmacol. 2001 Oct;60(4):753-60.
4. Yeung SY, et al. Br J Pharmacol. 2005 Oct;146(4):585-95.
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