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Mps1-IN-2

CAS No. 1228817-38-6

Mps1-IN-2( —— )

Catalog No. M10891 CAS No. 1228817-38-6

Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Mps1-IN-2
Note

Research use only, not for human use.
Brief Description

Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.
Description

Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.
In Vitro

Mps1-IN-2 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 145 nM and 12 nM. Mps1-IN-2 also shows high affinity for PLK1 and GAK with Kds of 61 and 140 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-2 can induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells.
In Vivo

——
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Kinesin
Recptor

Mps1
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

1228817-38-6
Formula Weight

480.6
Molecular Formula

C26H36N6O3
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

CCOC1=C(NC2=NC=C3N(C)C(=O)CCN(C4CCCC4)C3=N2)C=CC(=C1)N1CCC(O)CC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kwiatkowski N, et al. Nat Chem Biol. 2010 May;6(5):359-68.

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