A-1048400( A1048400 )

Catalog No. M10826 CAS No. 1219624-62-0

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Product Name

A-1048400
Note

Research use only, not for human use.
Brief Description

A novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.
Description

A novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively; shows no significant activity against L-type Ca2+ channels (IC50=28 uM); reverses tactile allodynia in model of capsaicin-induced secondary hypersensitivity (EC50=300-365 ng/ml), without effect on hemodynamic function; blocks native N- and T-type Ca2+ currents in rat dorsal root ganglion neurons (IC50=3.0 and 1.6 uM), attenuates nociceptive, neuropathic and inflammatory pain in vivo.Pain Discontinued.
In Vitro

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In Vivo

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Synonyms

A1048400
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

Calcium Channel
Research Area

Neurological Disease
Indication

Pain

CAS Number

1219624-62-0
Formula Weight

543.711
Molecular Formula

C36H37N3O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C1N(CC(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=O)CCCC1(C5=CC=CC=C5)C6=CC=CC=C6
Chemical Name

1-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl)-3,3-diphenylpiperidin-2-one

1. Scott VE, et al. Biochem Pharmacol. 2012 Feb 1;83(3):406-18.

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