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TCV-309 chloride

CAS No. 121494-09-5

TCV-309 chloride( TCV309 chloride | TCV 309 chloride )

Catalog No. M10802 CAS No. 121494-09-5

A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TCV-309 chloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.
  • Description
    A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively; potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 of 2.1 and 2.6 ug/kg (i.v.), respectively; also reverses PAF-induced hypotension and endotoxin-induced hypotension in rats.Coagulation DisorderPhase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    In rats, TCV-309 selectively inhibits the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 most potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.
  • Synonyms
    TCV309 chloride | TCV 309 chloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cardiovascular Disease
  • Indication
    Coagulation Disorder

Chemical Information

  • CAS Number
    121494-09-5
  • Formula Weight
    629.9724
  • Molecular Formula
    C30H34BrClN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 6.3 mg/mL
  • SMILES
    CCC[N+]1=CC(=CC(=C1)Br)C(=O)N(CCC(=O)NCCOC(=O)N2CCC3=CC=CC=C3C2)C4=CC=CC=C4.[Cl-]
  • Chemical Name
    Pyridinium, 3-bromo-5-[[[3-[[2-[[(3,4-dihydro-2(1H)-isoquinolinyl)carbonyl]oxy]ethyl]amino]-3-oxopropyl]phenylamino]carbonyl]-1-propyl-, chloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Terashita Z, et al. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55. 2. Motoyama N, et al. Eur J Pain. 2013 Sep;17(8):1156-67. 3. Kuipers B, et al. J Immunol. 1994 Mar 1;152(5):2438-46.
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