Cart
sales@molnova.com
Home - Products - Others - Other Targets - TCV-309 chloride

TCV-309 chloride

CAS No. 121494-09-5

TCV-309 chloride( TCV309 chloride | TCV 309 chloride )

Catalog No. M10802 CAS No. 121494-09-5

A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 209 Get Quote
50MG 1044 Get Quote
100MG 1566 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    TCV-309 chloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.
  • Description
    A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively; potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 of 2.1 and 2.6 ug/kg (i.v.), respectively; also reverses PAF-induced hypotension and endotoxin-induced hypotension in rats.Coagulation DisorderPhase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    In rats, TCV-309 selectively inhibits the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 most potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.
  • Synonyms
    TCV309 chloride | TCV 309 chloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cardiovascular Disease
  • Indication
    Coagulation Disorder

Chemical Information

  • CAS Number
    121494-09-5
  • Formula Weight
    629.9724
  • Molecular Formula
    C30H34BrClN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 6.3 mg/mL
  • SMILES
    CCC[N+]1=CC(=CC(=C1)Br)C(=O)N(CCC(=O)NCCOC(=O)N2CCC3=CC=CC=C3C2)C4=CC=CC=C4.[Cl-]
  • Chemical Name
    Pyridinium, 3-bromo-5-[[[3-[[2-[[(3,4-dihydro-2(1H)-isoquinolinyl)carbonyl]oxy]ethyl]amino]-3-oxopropyl]phenylamino]carbonyl]-1-propyl-, chloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Terashita Z, et al. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55. 2. Motoyama N, et al. Eur J Pain. 2013 Sep;17(8):1156-67. 3. Kuipers B, et al. J Immunol. 1994 Mar 1;152(5):2438-46.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • ELA-14 (human)

    Potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32. Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.

  • BAPTA-AM

    BAPTA-AM is a selective, membrane-permeable calcium chelator.

  • D-Fructose-16-diphos...

    Fosfructose trisodium is a cytoprotective natural sugar phosphate for the potential treatment of sickle cell anemia cardiovascular ischemia and asthma. It acts by stimulating anaerobic glycolysis which generates adenosine triphosphate under ischemic conditions.

Sign In Join Free