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TCV-309 chloride
CAS No. 121494-09-5
TCV-309 chloride( TCV309 chloride | TCV 309 chloride )
Catalog No. M10802 CAS No. 121494-09-5
A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 209 | Get Quote |
|
| 50MG | 1044 | Get Quote |
|
| 100MG | 1566 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTCV-309 chloride
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.
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DescriptionA highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively; potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 of 2.1 and 2.6 ug/kg (i.v.), respectively; also reverses PAF-induced hypotension and endotoxin-induced hypotension in rats.Coagulation DisorderPhase 2 Discontinued.
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In Vitro——
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In VivoIn rats, TCV-309 selectively inhibits the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 most potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.
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SynonymsTCV309 chloride | TCV 309 chloride
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaCardiovascular Disease
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IndicationCoagulation Disorder
Chemical Information
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CAS Number121494-09-5
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Formula Weight629.9724
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Molecular FormulaC30H34BrClN4O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 6.3 mg/mL
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SMILESCCC[N+]1=CC(=CC(=C1)Br)C(=O)N(CCC(=O)NCCOC(=O)N2CCC3=CC=CC=C3C2)C4=CC=CC=C4.[Cl-]
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Chemical NamePyridinium, 3-bromo-5-[[[3-[[2-[[(3,4-dihydro-2(1H)-isoquinolinyl)carbonyl]oxy]ethyl]amino]-3-oxopropyl]phenylamino]carbonyl]-1-propyl-, chloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Terashita Z, et al. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.
2. Motoyama N, et al. Eur J Pain. 2013 Sep;17(8):1156-67.
3. Kuipers B, et al. J Immunol. 1994 Mar 1;152(5):2438-46.
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