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NKTR-181
CAS No. 1211231-76-3
NKTR-181( NKTR 181 | NKTR181 | Loxicodegol )
Catalog No. M10788 CAS No. 1211231-76-3
A novel, long-acting and orally active, selective mu-opioid agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
|
| 50MG | 2322 | Get Quote |
|
| 100MG | 3060 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNKTR-181
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NoteResearch use only, not for human use.
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Brief DescriptionA novel, long-acting and orally active, selective mu-opioid agonist.
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DescriptionA novel, long-acting and orally active, selective mu-opioid agonist that displays higher binding affinity (Ki=237 nM) at the MOR than kappa and delta opioid receptors (>100-fold); demonstrates maximum analgesic activity comparable to that of oxycodone in hot-plate latency and acetic-acid writhing models, reduces its rate of entry across the blood-brain barrier compared with traditional mu-opioid agonists.Pain Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsNKTR 181 | NKTR181 | Loxicodegol
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioid Receptor
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1211231-76-3
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Formula Weight595.73
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Molecular FormulaC31H49NO10
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Purity>98% (HPLC)
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Solubility——
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SMILESO[C@]1([C@H](N(C)CC2)C3)[C@@]42C5=C3C=CC(OC)=C5O[C@H]4[C@@H](OCCOCCOCCOCCOCCOCCOC)CC1
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Chemical Name(4R,4aS,7S,7aR,12bS)-7-((2,5,8,11,14,17-hexaoxanonadecan-19-yl)oxy)-9-methoxy-3-methyl-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinolin-4a-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Miyazaki T, et al. J Pharmacol Exp Ther. 2017 Oct;363(1):104-113.
2. Webster L, et al. Pain Med. 2017 Mar 10. doi: 10.1093/pm/pnw344.
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