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PF-04971729
CAS No. 1210344-57-2
PF-04971729( Ertugliflozin | MK-8835 | PF-4971729 )
Catalog No. M10784 CAS No. 1210344-57-2
A potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | In Stock |
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| 10MG | 57 | In Stock |
|
| 50MG | 87 | In Stock |
|
| 100MG | 133 | In Stock |
|
| 200MG | 214 | In Stock |
|
| 500MG | 353 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-04971729
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2.
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DescriptionA potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2; shows >2000-fold selectivity over hSGLT1; demonstrates robust urinary glucose excretion in rats and an excellent preclinical safety profile.Diabetes Phase 3 Clinical(In Vitro):Ertugliflozin (PF-04971729) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro.(In Vivo):Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats.
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In Vitro——
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In Vivo——
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SynonymsErtugliflozin | MK-8835 | PF-4971729
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PathwayGPCR/G Protein
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TargetSGLT
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RecptorSGLT2
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number1210344-57-2
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Formula Weight436.8827
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Molecular FormulaC22H25ClO7
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 46 mg/mL
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SMILESO[C@@H]1[C@](O2)(CO)CO[C@]2(C3=CC=C(Cl)C(CC4=CC=C(C=C4)OCC)=C3)[C@H](O)[C@H]1O
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Chemical Nameβ-L-Idopyranose, 1,6-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mascitti V, et al. J Med Chem. 2011 Apr 28;54(8):2952-60.
2. Kalgutkar AS, et al. Drug Metab Dispos. 2011 Sep;39(9):1609-19.
3. Miao Z, et al. Drug Metab Dispos. 2013 Feb;41(2):445-56.
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