Cart
sales@molnova.com
FPL64176
CAS No. 120934-96-5
FPL64176( ARC-64176 | FPL-64176 )
Catalog No. M10781 CAS No. 120934-96-5
FPL64176 (ARC-64176) is a potent L-type Ca++ channel activator with EC50 of 16 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 61 | In Stock |
|
| 5MG | 76 | In Stock |
|
| 10MG | 122 | In Stock |
|
| 25MG | 264 | In Stock |
|
| 50MG | 477 | In Stock |
|
| 100MG | 695 | In Stock |
|
| 200MG | 977 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameFPL64176
-
NoteResearch use only, not for human use.
-
Brief DescriptionFPL64176 (ARC-64176) is a potent L-type Ca++ channel activator with EC50 of 16 nM.
-
DescriptionFPL64176 (ARC-64176) is a potent L-type Ca++ channel activator with EC50 of 16 nM; prolongs action potential duration and enhances contractility in guinea pig papillary muscle, induces contractile response with EC50 of 0.2 uM; produces biexponential tail current decays at -50 mV with fast and slow time constants of 4.30 +/- 0.30 and 44.52 +/- 4.56 msec, respectively; produces large increases in cardiac contractile force and diastolic blood pressure in anesthetized dogs (100 mg/kg, i.v.). Heart Failure Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsARC-64176 | FPL-64176
-
PathwayGPCR/G Protein
-
TargetCalcium Channel
-
RecptorCalcium Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number120934-96-5
-
Formula Weight347.414
-
Molecular FormulaC22H21NO3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (287.84 mM)
-
SMILESO=C(C1=C(C)NC(C)=C1C(C2=CC=CC=C2CC3=CC=CC=C3)=O)OC
-
Chemical Name2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Baxter AJ, et al. J Med Chem. 1993 Sep 17;36(19):2739-44.
2. Rampe D, et al. J Pharmacol Exp Ther. 1993 Jun;265(3):1125-30.
3. Zheng W, et al. Mol Pharmacol. 1991 Nov;40(5):734-41.
4. Liu L, et al. Neuropharmacology. 2003 Aug;45(2):281-92.
molnova catalog
related products
-
Etripamil
Etripamil displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells. Etripamil is an antagonist of short-acting L-type calcium-channel.
-
L-Phenylalanine
L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM.
-
RO2959 Hydrochloride
RO2959 hydrochloride is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
