Cart
sales@molnova.com
PF-46396
CAS No. 1207481-21-7
PF-46396( PF 46396 | PF46396 )
Catalog No. M10767 CAS No. 1207481-21-7
PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePF-46396
-
NoteResearch use only, not for human use.
-
Brief DescriptionPF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.
-
DescriptionPF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein; exhibits antiviral activity against 17/27 HIV-1 clinical isolates with EC50s ranging from 0.005 to 7 uM and TI values ranging from 2 to 3,400.
-
In Vitro——
-
In Vivo——
-
SynonymsPF 46396 | PF46396
-
PathwayMicrobiology/Virology
-
TargetHIV
-
RecptorHIV
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1207481-21-7
-
Formula Weight454.537
-
Molecular FormulaC27H29F3N2O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1C(C(F)(F)F)=CC=CN1CC(C2=CC=C(C(C)(C)C)C=C2)NC3CC4=C(C=CC=C4)C3
-
Chemical Name1-[2-(4-tert-butylphenyl)-2-(2,3-dihydro-1H-inden-2-ylamino)ethyl]-3-(trifluoromethyl)pyridin-2-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Blair WS, et al. Antimicrob Agents Chemother. 2009 Dec;53(12):5080-7.
2. Murgatroyd C, et al. J Virol. 2016 Aug 26;90(18):8181-97.
3. Waki K, et al. PLoS Pathog. 2012;8(11):e1002997.
molnova catalog
related products
-
HAR-171
HAR-171 is a small molecule gp120-CD40 blocker that acts as a highly potent HIV entry inhibitor with IC50 of 0.43 uM against YTA48P virus.
-
GS-6207
GS-6207 (GS6207, GS-CA1) is a potent, selective inhibitor of HIV-1 capsid function with potency and potential to be clinically effective against a broad range of HIV-1 strains.
-
Cyclotriazadisulfona...
Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
