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JNJ-42041935
CAS No. 1193383-09-3
JNJ-42041935( JNJ42041935 )
Catalog No. M10673 CAS No. 1193383-09-3
JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 46 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 211 | In Stock |
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| 50MG | 346 | In Stock |
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| 100MG | 555 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1172 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJNJ-42041935
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD.
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DescriptionJNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively; shows highly selectivity for PHD relative to FIH (pIC50=4.0); JNJ-42041935 is approximately equipotent in the HIF-1α accumulation and erythropoietin secretion assays in Hep3B cells as DMOG and 3,4-EDHB; reverses inflammation-induced anemia at dose of 100 μmol/kg, whereas erythropoietin has no effect.
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In Vitro——
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In Vivo——
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SynonymsJNJ42041935
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorPHD1|PHD2|PHD3
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1193383-09-3
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Formula Weight346.6493
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Molecular FormulaC12H6ClF3N4O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 36 mg/mL
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SMILESClC1=CC2=C(NC(N3C=C(C(O)=O)C=N3)=N2)C=C1OC(F)(F)F
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Chemical Name1H-Pyrazole-4-carboxylic acid, 1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barrett TD, et al. Mol Pharmacol. 2011 Jun;79(6):910-20.
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