CCR10 antagonist 1( —— )

Catalog No. M10657 CAS No. 1191031-97-6

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Product Name

CCR10 antagonist 1
Note

Research use only, not for human use.
Brief Description

CCR10 antagonist 1 is a potent, selective CCR10 antagonist with IC50 of 690 nM.
Description

CCR10 antagonist 1 is a potent, selective CCR10 antagonist with IC50 of 690 nM; demonstrates functional CCR1 antagonism by inhibiting the CCL27 dependent chemotaxis of Ba/F3 cells stably transfected with human CCR10 with an IC50 of 53 nM, exhibits no antagonism of murine CCL27 dependent Ca2+ flux in CHO-K cells stably transfected with murine CCR10 at 20 uM.
In Vitro

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In Vivo

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Synonyms

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Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

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Indication

——

CAS Number

1191031-97-6
Formula Weight

519.398
Molecular Formula

C19H24Cl2N6O5S
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

4-amino-3,5-dichloro-N-(1-(4-methylpiperidin-1-yl)-4-(2-nitro-1H-imidazol-1-yl)-1-oxobutan-2-yl)benzenesulfonamide

1. Abeywardane A, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283.

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