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KBU2046
CAS No. 1143863-69-7
KBU2046( KBU 2046 | KBU-2046 )
Catalog No. M10511 CAS No. 1143863-69-7
KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | Get Quote |
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| 5MG | 72 | Get Quote |
|
| 10MG | 102 | Get Quote |
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| 25MG | 215 | Get Quote |
|
| 50MG | 335 | Get Quote |
|
| 100MG | 507 | Get Quote |
|
| 500MG | 1062 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameKBU2046
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NoteResearch use only, not for human use.
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Brief DescriptionKBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.
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DescriptionKBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes; selectively disrupts heterocomplex function and inhibits cancer cell motility, only binds to HSP90β and CDC37 when both proteins are present, does not bind to either protein alone; decreases phosphorylation of HSP90β, inhibits cancer metastasis and prolongs life in vivo; KBU2046-mediated changes in the signature of client proteins bound to the HSP90β/CDC37 heterocomplex mediate effects upon cell motility.
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In Vitro——
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In Vivo——
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SynonymsKBU 2046 | KBU-2046
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP
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Research Area——
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Indication——
Chemical Information
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CAS Number1143863-69-7
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Formula Weight242.249
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Molecular FormulaC15H11FO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (206.40 mM)
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SMILESO=C1C(C2=CC=C(F)C=C2)COC3=C1C=CC=C3
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Chemical Name3-(4-fluorophenyl)chroman-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xu L, et al. Nat Commun. 2018 Jun 22;9(1):2454.
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