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KBU2046

CAS No. 1143863-69-7

KBU2046( KBU 2046 | KBU-2046 )

Catalog No. M10511 CAS No. 1143863-69-7

KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 50 In Stock
2MG 28 In Stock
5MG 46 In Stock
10MG 65 In Stock
25MG 136 In Stock
50MG 207 In Stock
100MG 314 In Stock
200MG 440 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    KBU2046
  • Note
    Research use only, not for human use.
  • Brief Description
    KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.
  • Description
    KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes; selectively disrupts heterocomplex function and inhibits cancer cell motility, only binds to HSP90β and CDC37 when both proteins are present, does not bind to either protein alone; decreases phosphorylation of HSP90β, inhibits cancer metastasis and prolongs life in vivo; KBU2046-mediated changes in the signature of client proteins bound to the HSP90β/CDC37 heterocomplex mediate effects upon cell motility.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KBU 2046 | KBU-2046
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1143863-69-7
  • Formula Weight
    242.249
  • Molecular Formula
    C15H11FO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (206.40 mM)
  • SMILES
    O=C1C(C2=CC=C(F)C=C2)COC3=C1C=CC=C3
  • Chemical Name
    3-(4-fluorophenyl)chroman-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xu L, et al. Nat Commun. 2018 Jun 22;9(1):2454.
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