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Emixustat hydrochloride

CAS No. 1141934-97-5

Emixustat hydrochloride( ACU-4429 hydrochloride )

Catalog No. M10504 CAS No. 1141934-97-5

Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 128 In Stock
2MG 77 In Stock
5MG 117 In Stock
10MG 187 In Stock
25MG 313 In Stock
50MG 458 In Stock
100MG 732 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Emixustat hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.
  • Description
    Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM; reduces the production of visual chromophore (11-cis retinal) in wild-type mice following a single oral dose (ED50 = 0.18 mg/kg).Other Indication Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ACU-4429 hydrochloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    1141934-97-5
  • Formula Weight
    299.8362
  • Molecular Formula
    C16H26ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 44 mg/mL
  • SMILES
    C1CCC(CC1)COC2=CC=CC(=C2)C(CCN)O.Cl
  • Chemical Name
    Benzenemethanol, α-(2-aminoethyl)-3-(cyclohexylmethoxy)-, hydrochloride (1:1), (αR)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kiser PD, et al. Nat Chem Biol. 2015 Jun;11(6):409-15. 2. Bavik C, et al. PLoS One. 2015 May 13;10(5):e0124940. 3. Zhang J, et al. J Clin Invest. 2015 Jul 1;125(7):2781-94.
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