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WYE-151650
CAS No. 1141855-86-8
WYE-151650( —— )
Catalog No. M10503 CAS No. 1141855-86-8
WYE-151650 is a novel potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameWYE-151650
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NoteResearch use only, not for human use.
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Brief DescriptionWYE-151650 is a novel potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively.
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DescriptionWYE-151650 is a novel potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively; inhibits IL-2-induced proliferation in human PBMC blasts with IC50 of 50 nM, inhibits IL-2-induced STAT-5 phosphorylation of lymphocytes, exhibits 10-29-fold less activity against JAK-3-independent IL-6- or GM-CSF-induced STAT phosphorylation; inhibits JAK-3-mediated IL-2-induced IFN-gamma production and decreases the natural killer cell population in mice, shows efficacy in mouse DTH and CIA models.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK
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Research Area——
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Indication——
Chemical Information
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CAS Number1141855-86-8
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Formula Weight435.487
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Molecular FormulaC26H21N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-[8,9-Dihydro-7-methyl-8-oxo-9-[(1R,4R)-1,2,3,4-tetrahydro-4-hydroxy-1-naphthalenyl]-7H-purin-2-yl]-1H-benzimidazole-6-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lin TH, et al. Arthritis Rheum. 2010 Aug;62(8):2283-93.
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