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LB-205

CAS No. 1113025-86-7

LB-205( LB 205 | LB205 )

Catalog No. M10416 CAS No. 1113025-86-7

A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo.

Purity : >98% (HPLC)

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Biological Information

Product Name

LB-205
Note

Research use only, not for human use.
Brief Description

A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo.
Description

A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo; significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA; up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax.
In Vitro

——
In Vivo

——
Synonyms

LB 205 | LB205
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

Chemical Information

CAS Number

1113025-86-7
Formula Weight

343.445
Molecular Formula

C18H21N3O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NCCCCCC(NC1=CC=CC=C1)=O)C2=CC=CC=C2S
Chemical Name

2-mercapto-N-(6-oxo-6-(pyridin-3-ylamino)hexyl)benzamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Lu J, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21200-5. 2. Lu J, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52.

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