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KT-5720
CAS No. 108068-98-0
KT-5720( KT5720 )
Catalog No. M10323 CAS No. 108068-98-0
KT-5720 is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameKT-5720
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NoteResearch use only, not for human use.
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Brief DescriptionKT-5720 is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM).
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DescriptionKT-5720 is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM); reversibly arrests human skin fibroblasts in the G1 phase.
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In Vitro——
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In VivoAnimal Model:MDR1 transgenic mice model.Dosage:5 mg/kg Administration:Intraperitoneal injection; single daily for 8 days Result:Exhibited the leukopenia induced by daunorubicin in the MDR mice was equivalent to that measured in non-MDR mice treated with daunorubicin alone.
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SynonymsKT5720
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PathwayApoptosis
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TargetPKA
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RecptorPKA
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Research Area——
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Indication——
Chemical Information
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CAS Number108068-98-0
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Formula Weight537.605
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Molecular FormulaC32H31N3O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Methanol :5 mg/mL (9.30 mM)
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SMILESO=C([C@](C[C@@](O1)([H])N2C3=CC=CC=C43)(O)[C@]1(C)N5C6=CC=CC=C6C7=C5C2=C4C8=C7CNC8=O)OCCCCCC
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Chemical Name9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10S,12S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gadbois DM, et al. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30.
2. Feng H, et al. Neuro Oncol. 2015 Jun;17(6):832-42.
3. Ott SR, et al. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E381-7.
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