CY-09( NLRP3 inhibitor CY-09 )

Catalog No. M10304 CAS No. 1073612-91-5

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Product Name

CY-09
Note

Research use only, not for human use.
Brief Description

CY-09 (NLRP3 inhibitor CY-09) is a selective and direct NLRP3 inhibitor.
Description

CY-09 (NLRP3 inhibitor CY-09) is a selective and direct NLRP3 inhibitor, binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity; suppresses NLRP3 inflammasome assembly and activation, shows remarkable therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes.
In Vitro

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In Vivo

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Synonyms

NLRP3 inhibitor CY-09
Pathway

NF-κB
Target

NOD
Recptor

NLRP3|NLRP3?inhibitor
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1073612-91-5
Formula Weight

423.424
Molecular Formula

C19H12F3NO3S2
Purity

>98% (HPLC)
Solubility

DMSO: 77 mg/mL (181.8 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(O)C1=CC=C(/C=C(SC(N2CC3=CC=CC(C(F)(F)F)=C3)=S)\C2=O)C=C1
Chemical Name

Benzoic acid, 4-[[4-oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]-

1. Jiang H, et al. J Exp Med. 2017 Nov 6;214(11):3219-3238.

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