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Tafenoquine
CAS No. 106635-80-7
Tafenoquine( SB-252263 | Tafenoquine | WR 238605 )
Catalog No. M10284 CAS No. 106635-80-7
Tafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | In Stock |
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| 5MG | 53 | In Stock |
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| 10MG | 86 | In Stock |
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| 25MG | 183 | In Stock |
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| 50MG | 290 | In Stock |
|
| 100MG | 461 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTafenoquine
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NoteResearch use only, not for human use.
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Brief DescriptionTafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.
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DescriptionTafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.Parasite Infection Phase 3 Clinical(In Vitro):Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg).
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In Vitro——
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In VivoTafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg).
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SynonymsSB-252263 | Tafenoquine | WR 238605
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PathwayMicrobiology/Virology
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TargetParasite
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RecptorParasite
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Research AreaInfection
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IndicationParasite Infection
Chemical Information
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CAS Number106635-80-7
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Formula Weight463.501
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Molecular FormulaC24H28F3N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC(=NC2=C1C(=C(C=C2NC(C)CCCN)OC)OC3=CC=CC(=C3)C(F)(F)F)OC
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Chemical NameN4-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)quinolin-8-yl)pentane-1,4-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shanks GD, et al. Clin Infect Dis. 2001 Dec 15;33(12):1968-74.
2. Ramharter M, et al. Am J Trop Med Hyg. 2002 Jul;67(1):39-43.
3. Pradines B, et al. Antimicrob Agents Chemother. 2006 Sep;50(9):3225-6.
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