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RO 3280

CAS No. 1062243-51-9

RO 3280( RO3280 | RO-3280 | RO 3280 | Ro5203280 )

Catalog No. M10275 CAS No. 1062243-51-9

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1)

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

RO 3280
Note

Research use only, not for human use.
Brief Description

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1)
Description

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3nM.
In Vitro

——
In Vivo

——
Synonyms

RO3280 | RO-3280 | RO 3280 | Ro5203280
Pathway

Cell Cycle/DNA Damage
Target

PLK
Recptor

PLK1
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

1062243-51-9
Formula Weight

543.61
Molecular Formula

C27H35F2N7O3
Purity

>98% (HPLC)
Solubility

Ethanol: 100 mg/mL (183.95 mM); DMSO: 100 mg/mL (183.95 mM)
SMILES

O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(N4C)C(N(C5CCCC5)CC(F)(F)C4=O)=N3)C(OC)=C2
Chemical Name

4-((9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Chen S, et al. Bioorg Med Chem Lett, 2012, 22(2), 1247-1250.

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