Carbendazim( Mercarzole | Carbendazole. Code name: FB462 )

Catalog No. M10269 CAS No. 10605-21-7

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Product Name

Carbendazim
Note

Research use only, not for human use.
Brief Description

Carbendazim is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities.
Description

Carbendazim is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities.(In Vitro):Carbendazim (4-60 μM; 24 hours) has no effects on viability of HeLa cells in a CCK-8 assay.(In Vivo):Carbendazim (oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days) induces hepatic lipid metabolism disorder, it results in a significant increase of hepatic lipid accumulation and triglyceride (TG) levels in mice.
In Vitro

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In Vivo

Animal Model:6-week-old male ICR miceDosage:100 and 500 mg/kg Administration:Oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days Result:Increased the relative mRNA levels of some key genes related to lipogenesis and TG synthesis.Up-regulated mRNA levels of IL-1b and IL-6 in the liver in mice.Increased the serum concentrations of 2 proinflammatory cytokines IL-1b and IL-6 at 500 mg/kg. However, in the fat tissues, onlyIL-1b in the CBZ-500-treated group increased significantly as compared with the control group.
Synonyms

Mercarzole | Carbendazole. Code name: FB462
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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1.Jiang J, et al. Toxicol In Vitro. 2015 Oct;29(7):1473-8

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