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Masitinib mesylate
CAS No. 1048007-93-7
Masitinib mesylate( AB1010 mesylate | AB-1010 mesylate | AB 1010 mesylate )
Catalog No. M10237 CAS No. 1048007-93-7
A potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
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| 25MG | 46 | In Stock |
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| 50MG | 68 | In Stock |
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| 100MG | 110 | In Stock |
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| 200MG | 166 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMasitinib mesylate
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NoteResearch use only, not for human use.
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Brief DescriptionA potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays.
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DescriptionA potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays; also inhibits Lyn, and to a lesser extent, FGFR3, and inhibits KIT gain-of-function mutants V559D (IC50=3.0 nM) and Δ27 mouse mutant (IC50=5 nM); dose-dependently inhibits SCF-induced cell proliferation in Ba/F3 cells expressing human wild-type KIT (IC50=150 nM); inhibits tumour growth in vivo.Prostate cancer Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAB1010 mesylate | AB-1010 mesylate | AB 1010 mesylate
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PathwayAngiogenesis
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Targetc-Kit
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Recptorc-Kit
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Research AreaCancer
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IndicationProstate Cancer
Chemical Information
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CAS Number1048007-93-7
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Formula Weight594.748
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Molecular FormulaC29H34N6O4S2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESO=C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)C4=CC=C(CN5CCN(C)CC5)C=C4.OS(=O)(C)=O
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Chemical NameBenzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-, methanesulfonate (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dubreuil P, et al. PLoS One. 2009 Sep 30;4(9):e7258.
2. Humbert M, et al. Allergy. 2009 Aug;64(8):1194-201.
3. Tebib J, et al. Arthritis Res Ther. 2009;11(3):R95.
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