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Pramipexole

CAS No. 104632-26-0

Pramipexole( Pramipexole | Oprymea | Pramipexol | Pramipexolum )

Catalog No. M10228 CAS No. 104632-26-0

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pramipexole
  • Note
    Research use only, not for human use.
  • Brief Description
    A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.
  • Description
    A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively; also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors; used for treating Parkinson's disease (PD) and restless legs syndrome (RLS).Parkinson's Disease Approved.
  • In Vitro
    Pramipexole shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM.Pramipexole (0.01-10?μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size.Pramipexole attenuates levodopa-induced toxicity in mesencephalic cultures.
  • In Vivo
    Pramipexole (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals.Pramipexole improves neurological recovery.Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Animal Model:Male Wistar rats weighing 250-300 g (16-18 weeks old)Dosage:0.25 mg/kg, 1 mg/kg Administration:Intraperitoneal injection Result:Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
  • Synonyms
    Pramipexole | Oprymea | Pramipexol | Pramipexolum
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    D2L|D3|D4
  • Research Area
    Neurological Disease
  • Indication
    Parkinson Disease

Chemical Information

  • CAS Number
    104632-26-0
  • Formula Weight
    211.3271
  • Molecular Formula
    C10H17N3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCCN[C@H](C1)CCC2=C1SC(N)=N2
  • Chemical Name
    2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Newman-Tancredi A, et al. J Pharmacol Exp Ther. 2002 Nov;303(2):805-14. 2. Kvernmo T, et al. Clin Ther. 2006 Aug;28(8):1065-78. 3. Millan MJ, et al. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804.
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