Cart
sales@molnova.com
GNE-490
CAS No. 1033739-92-2
GNE-490( GNE490 )
Catalog No. M10164 CAS No. 1033739-92-2
GNE-490 is a potent, selective, orally available class I PI3K inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 204 | In Stock |
|
| 2MG | 111 | In Stock |
|
| 5MG | 188 | In Stock |
|
| 10MG | 321 | In Stock |
|
| 25MG | 508 | In Stock |
|
| 50MG | 686 | In Stock |
|
| 100MG | 911 | In Stock |
|
| 200MG | 1256 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameGNE-490
-
NoteResearch use only, not for human use.
-
Brief DescriptionGNE-490 is a potent, selective, orally available class I PI3K inhibitor.
-
DescriptionGNE-490 is a potent, selective, orally available class I PI3K inhibitor with IC50 of 3.5/25/5.2/15 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ; shows >200-fold selectivity over mTOR (IC50=740 nM); has good PK profiles, and are efficacious in xenograft models.
-
In Vitro——
-
In Vivo——
-
SynonymsGNE490
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI3K
-
RecptorPI3K
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1033739-92-2
-
Formula Weight386.474
-
Molecular FormulaC18H22N6O2S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : ≥ 100 mg/mL (258.75 mM)
-
SMILESCC1=NC(=NC=C1C2=NC3=C(C(=N2)N4CCOCC4)SC(=C3)C(C)(C)O)N
-
Chemical Name2-(2-Amino-4-methyl-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Sutherlin DP, et al. J Med Chem. 2010 Feb 11;53(3):1086-97.
2. Sampath D, et al. Neoplasia. 2013 Jul;15(7):694-711.
molnova catalog
related products
-
RLY-2608
RLY-2608 is a selective mutant PI3Kα inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.
-
PI3Kδ-IN-7n
PI3Kδ-IN-7n is a highly potent and selective PI3Kδ inhibitor with IC50 of 0.9 nM.
-
PI-103 hydrochloride
A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.
