E1231( E-1231 )

Catalog No. M10151 CAS No. 1031195-19-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

E1231
Note

Research use only, not for human use.
Brief Description

E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM.
Description

E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα); increases ATP-binding cassette transporter A1 (ABCA1) expression in RAW 264.7 cells dependent on SIRT1 and LXRα, promotes cholesterol efflux and inhibited lipid accumulation in RAW 264.7 cells via SIRT1 and ABCA1; decreases total cholesterol and triglyceride levels in both serum and the liver in golden hamster hyperlipidemia models.
In Vitro

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In Vivo

Animal Model:HFD-diet Golden hamsters (80-90 g)Dosage:40 mg/kg Administration:PO; once daily for 7 days Result:Increased SIRT1 protein expression but not SIRT3, SIRT6, or SIRT7. And reduced liver and serum cholesterol in hamsters.Animal Model:Atherogenic diet ApoE-/- miceDosage:25, 50, and 100 mg/kg Administration:PO; once daily for 12 weeks Result:Modulated plaque composition, immunofluorescence staining. And reduced CD68 positive areas while increasing ABCA1 expression in the aortic sinus.
Synonyms

E-1231
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Sirtuin
Research Area

——
Indication

——

CAS Number

1031195-19-3
Formula Weight

363.417
Molecular Formula

C21H21N3O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (275.17 mM)
SMILES

CC(N1CCN(C(C2=CC(C3=CC=C(C)O3)=NC4=CC=CC=C24)=O)CC1)=O
Chemical Name

1-(4-(2-(5-methylfuran-2-yl)quinoline-4-carbonyl)piperazin-1-yl)ethan-1-one

1. Feng T, et al. Atherosclerosis. 2018 Jul;274:172-181.

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