Suvorexant( MK-4305 )

Catalog No. M10147 CAS No. 1030377-33-3

A potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively.

Purity : >98% (HPLC)

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Biological Information

Product Name

Suvorexant
Note

Research use only, not for human use.
Brief Description

A potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively.
Description

A potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively; significantly and dose-dependently reduces locomotor activity and promotes sleep in rats.Sleep Disorder Launched.
In Vitro

——
In Vivo

——
Synonyms

MK-4305
Pathway

GPCR/G Protein
Target

Orexin Receptor
Recptor

Orexin Receptor
Research Area

Neurological Disease
Indication

Sleep Disorder

Chemical Information

CAS Number

1030377-33-3
Formula Weight

450.92
Molecular Formula

C23H23ClN6O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(N1CCN(C2=NC3=CC(Cl)=CC=C3O2)CC[C@H]1C)C4=CC(C)=CC=C4N5N=CC=N5
Chemical Name

(R)-(4-(5-chlorobenzo[d]oxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Cox CD, et al. J Med Chem. 2010 Jul 22;53(14):5320-32. 2. Winrow CJ, et al. J Neurogenet. 2011 Mar;25(1-2):52-61. 3. Sun H, et al. Sleep. 2013 Feb 1;36(2):259-67. 4. Hopkins CR. ACS Chem Neurosci. 2012 Sep 19;3(9):647-8.

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