PF-04191834( PF-4191834 )

Catalog No. M10139 CAS No. 1029317-21-2

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HPLC

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Product Name

PF-04191834
Note

Research use only, not for human use.
Brief Description

PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM.
Description

PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM; displays 300‐fold over 12‐LO and 15‐LO, and no inhibition of the cyclooxygenase enzymes; is under clinical investigation for the oral treatment of asthma and pain.Pain Phase 2 Discontinued.
In Vitro

——
In Vivo

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Synonyms

PF-4191834
Pathway

Immunology/Inflammation
Target

Lipoxygenase
Recptor

Lipoxygenase
Research Area

Neurological Disease
Indication

Pain

CAS Number

1029317-21-2
Formula Weight

393.502
Molecular Formula

C22H23N3O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (254.13 mM)
SMILES

O=C(C1(C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)CCOCC1)N
Chemical Name

4-(3-((4-(1-methyl-1H-pyrazol-5-yl)phenyl)thio)phenyl)tetrahydro-2H-pyran-4-carboxamide

1. Masferrer JL, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301. 2. Rzodkiewicz P, et al. Reumatologia. 2016;54(4):161-164. Epub 2016 Oct 5.

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