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Home - Products - Membrane Transporter/Ion Channel - iGluR - GYKI 52466 dihydrochloride

GYKI 52466 dihydrochloride

CAS No. 102771-26-6

GYKI 52466 dihydrochloride( GYKI52466 dihydrochloride )

Catalog No. M10135 CAS No. 102771-26-6

GYKI 52466 is a selective, non-competitive, orally active AMPA receptor (AMPAR) antagonist with IC50 of 10-20 uM against AMPA-induced responses.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    GYKI 52466 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    GYKI 52466 is a selective, non-competitive, orally active AMPA receptor (AMPAR) antagonist with IC50 of 10-20 uM against AMPA-induced responses.
  • Description
    GYKI 52466 is a selective, non-competitive, orally active AMPA receptor (AMPAR) antagonist with IC50 of 10-20 uM against AMPA-induced responses; displays >20-fold selectivity over kainate and NMDA receptors; shows anticonvulsant and neuroprotective properties.Alzheimer Disease Discontinued.
  • In Vitro
    GYKI 52466 (0.3-100 μM) inhibits inward currents activated by AMPA and Kainate receptor in cultured rat hippocampal neurons.
  • In Vivo
    GYKI 52466 (intraperitoneal injection; 1.76-13.2 mg/kg; once) treatment provides potent anticonvulsant protection against sound-induced seizures in DBA/2 mice. Animal Model:Male and female DBA/2 mice tested for sound-induced seizure responses Dosage:1.76-13.2 mg/kg Administration:Intraperitoneal injection; 1.76-13.2 mg/kg; once Result:Observed Maximal anticonvulsant protection after the i.p. treatment (5-15 min ).
  • Synonyms
    GYKI52466 dihydrochloride
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    iGluR
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    102771-26-6
  • Formula Weight
    366.24
  • Molecular Formula
    C17H15N3O2.2HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    NC1=CC=C(C2=NN=C(C)CC3=CC4=C(OCO4)C=C32)C=C1
  • Chemical Name
    4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenamine dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tarnawa I, et al. Eur J Pharmacol. 1989 Aug 22;167(2):193-9. 2. Ouardouz M, et al. Neurosci Lett. 1991 Apr 15;125(1):5-8. 3. Donevan SD, et al. Neuron. 1993 Jan;10(1):51-9.
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