KR-33494( KR 33494 | KR33494 )

Catalog No. M10102 CAS No. 1021497-97-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

KR-33494
Note

Research use only, not for human use.
Brief Description

A potent inhibitor for Fas-mediated cell death, FAF1, inhibits ischemic cell death.
Description

A potent inhibitor for Fas-mediated cell death, FAF1, inhibits ischemic cell death.
In Vitro

——
In Vivo

Body weight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period. The dose-normalized AUClast is not significantly different between the groups, suggesting that KR-33493 is governed by linear kinetics.
Synonyms

KR 33494 | KR33494
Pathway

Apoptosis
Target

Fas Receptor
Recptor

Fas Receptor
Research Area

——
Indication

——

CAS Number

1021497-97-1
Formula Weight

460.3442
Molecular Formula

C20H18BrN3O3S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 31 mg/mL
SMILES

O=C(C1=NN(CCC2=CC=CC=C2)C=C1NC(CSC3=CC=C(Br)C=C3)=O)O
Chemical Name

1H-Pyrazole-3-carboxylic acid, 4-[[2-[(4-bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-

1. Yoo SE, et al. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1169-72. 2. Suh J, et al. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6362-5.

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