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MK-3577
CAS No. 1019112-29-8
MK-3577( MK 3577 | MK3577 )
Catalog No. M10091 CAS No. 1019112-29-8
A potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
|
| 50MG | 2322 | Get Quote |
|
| 100MG | 3060 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameMK-3577
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM.
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DescriptionA potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM; inhibits glucagon-mediated cAMP increases in CHO cells expressing the human glucagon receptor with IC50 of 8.3 nM.Diabetes Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsMK 3577 | MK3577
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PathwayGPCR/G Protein
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TargetGlucagon Receptor
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RecptorGlucagon Receptor
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number1019112-29-8
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Formula Weight521.03
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Molecular FormulaC30H30ClFN2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCC(C1=CC=C(C=C1)C(=O)NCCC(=O)O)C(C2=CC=C(C=C2)Cl)C3=CNC4=C3C=C(C=C4F)C
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Chemical Name3-(4-((1R,2S)-1-(4-chlorophenyl)-1-(7-fluoro-5-methyl-1H-indol-3-yl)pentan-2-yl)benzamido)propanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Glucagon-like peptid...
Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.Pancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on food intake in rats and does not enhance pancreatic insulin secretion.
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PF-06882961
PF-06882961 is an orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist. PF-06882961 shows mild to moderate damage to the heart, moderate to severe effects on the thymus gland (which helps with managing infection), mild to moderate stomach ulcers at the highest dose level given in the rat.
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GLP-1R agonist 3
GLP-1R agonist 3 is a potent imidazole derivative and GLP-1R agonist with demonstrated research potential in diabetes. [Thickened]
