MK-3577( MK 3577 | MK3577 )

Catalog No. M10091 CAS No. 1019112-29-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MK-3577
Note

Research use only, not for human use.
Brief Description

A potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM.
Description

A potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM; inhibits glucagon-mediated cAMP increases in CHO cells expressing the human glucagon receptor with IC50 of 8.3 nM.Diabetes Phase 2 Discontinued.
In Vitro

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In Vivo

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Synonyms

MK 3577 | MK3577
Pathway

GPCR/G Protein
Target

Glucagon Receptor
Recptor

Glucagon Receptor
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

1019112-29-8
Formula Weight

521.03
Molecular Formula

C30H30ClFN2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCC(C1=CC=C(C=C1)C(=O)NCCC(=O)O)C(C2=CC=C(C=C2)Cl)C3=CNC4=C3C=C(C=C4F)C
Chemical Name

3-(4-((1R,2S)-1-(4-chlorophenyl)-1-(7-fluoro-5-methyl-1H-indol-3-yl)pentan-2-yl)benzamido)propanoic acid

1. Peng JZ, et al. AAPS J. 2014 Nov;16(6):1259-70.

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