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CRS-3123
CAS No. 1013915-71-3
CRS-3123( CRS3123 | REP 3123 )
Catalog No. M10078 CAS No. 1013915-71-3
A novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1323 | Get Quote |
|
| 50MG | 2682 | Get Quote |
|
| 100MG | 3600 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCRS-3123
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NoteResearch use only, not for human use.
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Brief DescriptionA novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI).
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DescriptionA novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI); inhibits de novo toxin production in high cell density, stationary phase cultures of C. difficile at 1 mg/L; demonstrates efficacy in the hamster model of CDI and is superior to vancomycin 0.5 mg/kg in CDI model.Bacterial Infection Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsCRS3123 | REP 3123
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research AreaInfection
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IndicationBacterial Infection
Chemical Information
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CAS Number1013915-71-3
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Formula Weight515.264
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Molecular FormulaC19H21Br2N3O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (194.84 mM)
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SMILESBrC1=CC(Br)=C2OCC[C@H](C2=C1)NCCCNC3=CC(C4SC=CC4N3)=O
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Chemical Name5-((3-(((R)-6,8-dibromochroman-4-yl)amino)propyl)amino)-3a,7a-dihydrothieno[3,2-b]pyridin-7(4H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Citron DM, et al. J Antimicrob Chemother. 2009 May;63(5):972-6.
2. Ochsner UA, et al. J Antimicrob Chemother. 2009 May;63(5):964-71.
3. Critchley IA, et al. J Antimicrob Chemother. 2009 May;63(5):954-63.
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