MMBO( —— )

Catalog No. M10043 CAS No. 1005203-15-5

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Product Name

MMBO
Note

Research use only, not for human use.
Brief Description

MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively.
Description

MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively; inhibits tau phosphorylation in primary neural cell culture and also in normal mouse brain, significantly decreases hippocampal tau phosphorylation at GSK-3 sites in transgenic mouse model of AD; suppresses tau pathology as assessed by AT8-immunoreactivity without affecting amyloid β pathology, significantly improves memory and cognitive deficits in AD models.
In Vitro

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In Vivo

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Synonyms

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Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

GSK-3
Research Area

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Indication

——

CAS Number

1005203-15-5
Formula Weight

338.381
Molecular Formula

C18H14N2O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=NN=C(O1)C2=CC3=C(C=C2)OC=C3C4=CC=C(C=C4)S(=O)C
Chemical Name

2-methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole

1. Onishi T, et al. J Neurochem. 2011 Dec;119(6):1330-40.

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