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Ly93
CAS No. 1883528-69-5
Ly93( —— )
Catalog No. M33417 CAS No. 1883528-69-5
Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50: 91 nM) used for studying atherosclerosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 150 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameLy93
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NoteResearch use only, not for human use.
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Brief DescriptionLy93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50: 91 nM) used for studying atherosclerosis.
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DescriptionLy93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM.
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In Vitro——
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In VivoLy93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice.Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice.Animal Model:C57BL/6J mice.Dosage:100 mg/kg.Administration:I.G. (gavage) once daily for 7 days.Result:Significantly decreased the plasma SM levels compared with vehicle group.Animal Model:ApoE KO mice (eight-week-old).Dosage:12.5 or 40 mg/kg.Administration:I.G. (gavage) once daily.Result:The levels of ALT and AST in the plasma of apoE KO mice did not show statistic changes when compared with the control group.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1883528-69-5
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Formula Weight332.4
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Molecular FormulaC21H20N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (752.11 mM; Ultrasonic )
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SMILESCCc1ccccc1COc1ccccc1C(=O)Nc1cccnc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882.?
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