Loxoribine

Research use only, not for human use.

Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.

Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway. Loxoribine causes maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability. Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54, and CCR7. In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells.

Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability.Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7.loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway.

Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo. Animal Model:8-12 weeks male CBA/J mice Dosage:2 mg Administration:Subcutaneous or intravenous injection Result:activates murine natural killer (NK) cells in vivo.

7-Allyl-8-oxoguanosine,RWJ 21757

Immunology/Inflammation

TLR

TLR7

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121288-39-9

339.3

C13H17N5O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (294.72 mM)

Nc1nc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(=O)n(CC=C)c2c(=O)[nH]1

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(-20℃)

With Ice Pack

≥ 2 years