Loreclezole( —— )

Catalog No. M20110 CAS No. 117857-45-1

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Product Name

Loreclezole
Note

Research use only, not for human use.
Brief Description

Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
Description

Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
In Vitro

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In Vivo

Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test. Animal Model:Adult male Lister Hooded rats.Dosage:10, 25, 50 or 75 mg/kg.Administration:IP, 60 min before measurement of seizure threshold.Result:Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

GABAA
Research Area

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Indication

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1.Donnelly JL et al. Loreclezole enhances apparent desensitization of recombinant GABAA receptor currents. Neuropharmacology. 1996;35(9-10):1233-41.

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