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Linopirdine

CAS No. 105431-72-9

Linopirdine( DUP-996 | Linopirine )

Catalog No. M10251 CAS No. 105431-72-9

Linopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 46 Get Quote
5MG 72 Get Quote
10MG 115 Get Quote
25MG 215 Get Quote
50MG 372 Get Quote
100MG 531 Get Quote
200MG 768 Get Quote
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Biological Information

  • Product Name
    Linopirdine
  • Note
    Research use only, not for human use.
  • Brief Description
    Linopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
  • Description
    Linopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM); inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo.Alzheimer Disease Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague-Dawley rats (300-350 g)Dosage:0.1, 0.5, 1, 3, 6 mg/kg Administration:5 intravenous bolus injections of increasing dosesResult:Transiently and dose-dependently increases MAP by up to 15%.
  • Synonyms
    DUP-996 | Linopirine
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    105431-72-9
  • Formula Weight
    391.465
  • Molecular Formula
    C26H21N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (319.32 mM)
  • SMILES
    O=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)C1(CC4=CC=NC=C4)CC5=CC=NC=C5
  • Chemical Name
    1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17. 2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3. 3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
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