Cart
sales@molnova.com
LP-922761
CAS No. 1454808-95-7
LP-922761( —— )
Catalog No. M33411 CAS No. 1454808-95-7
LP-922761 is a potent, selective, and orally active AAK1 inhibitor with inhibitory effects on BMP-2 induced protein kinase (BIKE).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 123 | Get Quote |
|
| 10MG | 202 | Get Quote |
|
| 25MG | 351 | Get Quote |
|
| 50MG | 523 | Get Quote |
|
| 100MG | 732 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameLP-922761
-
NoteResearch use only, not for human use.
-
Brief DescriptionLP-922761 is a potent, selective, and orally active AAK1 inhibitor with inhibitory effects on BMP-2 induced protein kinase (BIKE).
-
DescriptionLP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively.LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorAAK1 (AP2 associated kinase 1)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1454808-95-7
-
Formula Weight410.47
-
Molecular FormulaC21H26N6O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 41.67 mg/mL (101.52 mM; Ultrasonic (<80°C)
-
SMILESCN(CCNc1ccc2ncc(-c3ccc(cc3)C(N)=O)n2n1)C(=O)OC(C)(C)C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.?
molnova catalog
related products
-
Leu-Valorphin-Arg
Leu-Valorphin-Arg
-
Azacosterol
Azacosterol (Diazasterol) is a DHCR24 inhibitor.Azacosterol undergoes a series of reactions in cortical neurons following oral or intraperitoneal administration.
-
Mc-Val-Cit-PAB-Cl
Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE.
