LMD-009( LMD 009 | LMD009 )

Catalog No. M16794 CAS No. 950195-51-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LMD-009
Note

Research use only, not for human use.
Brief Description

LMD-009 (LMD 009, LMD009) is a potent, selective, nonpeptide CCR8 agonist.
Description

LMD-009 (LMD 009, LMD009) is a potent, selective, nonpeptide CCR8 agonist that stimulates CCR8-mediated chemotaxis, inositol phosphate accumulation and calcium release with EC50 of 11-87 nM; displays no activity against other chemokine receptors.
In Vitro

Cell Viability Assay Cell Line:COS-7 cells Concentration:0-20 nM Incubation Time:90 min Result:Stimulated inositol phosphate accumulation in COS-7 cells expressing the human CCR8 receptor with an EC50 value of 11 nM. Inhibited none of the receptors of other human chemokine receptors.Cell Viability Assay Cell Line:Chinese hamster ovary cells Concentration:0-100 nM Incubation Time:1 hour Result:Regulated calcium release in Chinese hamster ovary cells with an EC50 value 87 nM.Cell Migration Assay Cell Line:Lymphocyte L1.2 cells.Concentration:0.1 nM- 100 μM Incubation Time:40 min Result:Exhibited an Ki value of 66 nM with L1.2 cells and specifically bound 125I-CCL1.
In Vivo

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Synonyms

LMD 009 | LMD009
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

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Indication

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CAS Number

950195-51-4
Formula Weight

471.601
Molecular Formula

C29H33N3O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (530.12 mM)
SMILES

O=C1NCN(CCC2=CC=CC=C2)C13CCN(CC4=CC=CC(OC5=CC=CC=C5OC)=C4)CC3
Chemical Name

8-[3-(2-methoxyphenoxy)benzyl]-1-phenethyl-1,3,8-triaza-spiro[4.5]decan-4-one

1. Jensen PC, et al. Mol Pharmacol. 2007 Aug;72(2):327-40.

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