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L162389

CAS No. 169281-53-2

L162389( —— )

Catalog No. M32992 CAS No. 169281-53-2

L162389 is an orally active and potent angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor subtypes that stimulates the conversion of phosphatidylinositol.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    L162389
  • Note
    Research use only, not for human use.
  • Brief Description
    L162389 is an orally active and potent angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor subtypes that stimulates the conversion of phosphatidylinositol.
  • Description
    L162389 is a potent antagonist of angiotensin AT1 receptor with Ki of 28 nM.
  • In Vitro
    L-162,389 stimulates phosphatidylinositol turnover, albeit only to a small percentage of the angiotensin response. L-162,389 acts as angiotensin antagonist with IC50 value of 105 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    RAAS
  • Recptor
    RAAS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    169281-53-2
  • Formula Weight
    562.72
  • Molecular Formula
    C31H38N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(OCCCC)NS(=O)(=O)C=1C=CC(=CC1C2=CC=C(C=C2)CN3C4=NC(=CC(=C4N=C3CC)C)C)CCC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Perlman S, et al. Dual agonistic and antagonistic property of nonpeptide angiotensin AT1 ligands: susceptibility to receptor mutations. Mol Pharmacol. 1997 Feb;51(2):301-11.?
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