L-701324

Research use only, not for human use.

A potent, orally active antagonist at the glycine modulatory site on NMDA receptor with IC50 of 2 nM.

A potent, orally active antagonist at the glycine modulatory site on NMDA receptor with IC50 of 2 nM; is a potent, p.o. active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents.Anxiety Discontinued.

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L-701324 (5-10 mg/kg; i.p.; once) exhibits antidepressant-like potential in the forced swim test (FST) and tail suspension test (TST) without affecting the locomotor activity of mice.L-701324 (5-10 mg/kg; i.p.; daily, for 2 weeks) produces strong antidepressant-like effects in the chronic unpredictable mild stress (CUMS) model of depression and prevents the CUMS-induced decreases in eurogenesis and the BDNF signaling cascade in the hippocampus. L-701324 (2.5-5 mg/kg; p.o.; once) inhibits NMDA receptor activity via a blockade of the NMDA/glycine-sensitive site at the NMDA receptor is accompanied by a reduction of anxiety-like behavior in both non-conditioned and conditioned conflict behavior situations. Animal Model:Male C57BL/6 J mice in the chronic unpredictable mild stress (CUMS) (7 weeks of age) Dosage:5 and 10 mg/kg Administration:Intraperitoneal injection; daily, for 2 weeks Result:Reduced the immobility of C57BL/6 J mice.Increased the expression of BDNF, pTrkB and pCREB in the hippocampus.Animal Model:Male C57BL/6 J mice in the forced swim test (FST) and tail suspension test (TST) (7 weeks of age)Dosage:5 and 10 mg/kg Administration:Intraperitoneal injection; once Result:Reduced the immobility of C57BL/6 J mice in the FST and TST.Animal Model:Male Sprague-Dawley rats (280-300 g)Dosage:2.5 and 5 mg/kg Administration:Oral administration; once Result:Increased in the percentage of time spent in the open arm in a dose-dependent.Increased punished responding in the Vogel's conflict test in a dose-dependent fashion.

L-701,324

Membrane Transporter/Ion Channel

iGluR

NMDA receptor

Neurological Disease

Anxiety

142326-59-8

363.7938

C21H14ClNO3

>98% (HPLC)

DMSO: ≥ 34 mg/mL

O=C1NC2=C(C=CC(Cl)=C2)C(O)=C1C3=CC=CC(OC4=CC=CC=C4)=C3

2(1H)-Quinolinone, 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-

(-20℃)

With Ice Pack

≥ 2 years